Rare Endocrinology News
Spotlight On
Central diabetes insipidus
Central diabetes insipidus, also called neurogenic diabetes insipidus, is a type of diabetes insipidus due to a lack of vasopressin (ADH) production in the brain
Prevalence
1-9 / 100 000
Age of Onset
ICD-10
E23.2
Inheritance
Autosomal dominant
Autosomal recessive
Mitochondrial/Multigenic
X-linked dominant
X-linked recessive
5 Facts you should know
FACT
A type of diabetes insipidus due to a lack of vasopressin (ADH) production in the brain
FACT
Vasopressin acts to increase the volume of blood (intravascularly), and decrease the volume of urine produced
FACT
The major symptoms of include urinating polyuria, nocturia and polydipsia
FACT
The only symptom that CDI has in common with diabetes mellitus is polyuria
FACT
Diagnosis is by water deprivation test showing failure to maximally concentrate urine
Interest over time
Google searches
Common signs & symptoms
Anorexia
Polydipsia
Extreme thirst
Failure to thrive
Weight faltering
Nocturia
Anxiety
Excessive, persistent worry and fear
Hyponatremia
Low blood sodium levels
Fever
Excessive daytime somnolence
Top Clinical Trials
Title | Description | Phases | Status | Interventions | More Information |
---|---|---|---|---|---|
Effects of Intranasal Oxytocin in Patients With Central Diabetes Insipidus | This is a randomized, double-blind, placebo-controlled crossover pilot study of single-dose intranasal oxytocin (4 IU and 24 IU) in 18-60-year-old men and women with central diabetes insipidus to evaluate the effect of oxytocin on anxiety, depression and socioemotional functioning. | Phase 1 | Not yet recruiting | Drug: Oxytocin nasal spray | Learn more |
PB to Treat Hereditary Nephrogenic Diabetes Insipidus, ADPKD Treated With Tolvaptan, and Severely Polyuric Patients With Previous Lithium Administration | he purpose of this research is to study the effectiveness and safety of the medication PB in slowing the frequent urination related to tolvaptan as long-term treatment of Autosomal Dominant Polycystic Kidney Disease (ADPKD), or frequent urination related to inherited nephrogenic diabetes insipidus as an inherited condition or as an acquired condition from prior treatment with lithium. | Phase 2 | Recruiting | Drug: PB | Learn more |
Top Treatments in Research
Agent | Class/Mechanism of Action | Development Status | Company | Clinical Studies | More Information |
---|---|---|---|---|---|
Oxytocin nasal spray | The two main actions of oxytocin in the body are contraction of the womb (uterus) during childbirth and lactation. Oxytocin stimulates the uterine muscles to contract and also increases production of prostaglandins, which increase the contractions further. Men with central diabetes insipidus (CDI) have reduced plasma oxytocin levels and increased psychopathology. | Phase 1 | Elizabeth Austen Lawson|Massachusetts General Hospital | Learn more | More information |