Rare Endocrinology News
Spotlight On
Addison's disease
Addison's disease is a rare long-term endocrine disorder characterized by inadequate production of the steroid hormones cortisol and aldosterone by the two outer layers of the cells of the adrenal glands, causing adrenal insufficiency
Prevalence
1-5 / 10 000
Age of Onset
ICD-10
E27.1
Inheritance
This condition does not appear to have a clear pattern of inheritance.
5 Facts you should know
FACT
Symptoms generally come on slowly and may include abdominal pain and gastrointestinal abnormalities, weakness, and weight loss
FACT
Other major symptoms include fatigue, gastrointestinal abnormalities, and pigmentation
FACT
It occurs most frequently in middle-aged females
FACT
Increased excretion of water and hypotension can lead to dehydration, some people have cravings for salty foods due to the loss of sodium
FACT
Severe infections, vomiting, or diarrhea can precipitate an Addisonian crisis
Interest over time
Common signs & symptoms
Fatigue
Loss of appetite
Abdominal pain
Mood or behavior changes
Dark patches of skin (hyperpigmentation)
Muscle weakness or pain
Dehydration
Low blood pressure
Current treatments
Treatment for Addison's disease is focused on managing the symptoms. Treatment may include daily medicines that replace the adrenal hormones. Treatment for an adrenal crisis may include intravenous hydrocortisone, fluids, and electrolytes, as well as drugs that normalize blood pressure. People with Addison's disease should carry a medical ID that states the disease and emergency instructions. Specialists involved in the care of someone with Addison's disease may include: