Rare Endocrinology News
5 Facts you should know about
Wolman disease
1
WD is the most severe type of lysosomal acid lipase deficiency
2
Onset is usually seen in the first weeks of life with, abdominal distension and major and massive hepatosplenomegaly
3
Common symptoms in infants include enlarged liver and spleen, poor weight gain, low muscle tone, jaundice, vomiting, diarrhea, developmental delay, anemia, and poor absorption of nutrients from food
4
Complete absence of LAL activity causes Wolman Disease, which is normally fatal within the first 6 months of life
5
The presence of calcified adrenal glands is a common and very characteristic sign
Rare Endocrinology News
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