5 Facts you should know about

PIK3CA-related overgrowth spectrum (PROS)

“Overgrowth disorders” refers to the broad range of medical conditions characterized by excess tissue growth

A number of these overgrowth disorders are now understood to share a single cause: somatic mutations of the PIK3CA gene

There is a potential for misdiagnosis of PROS due to clinical overlap with other overgrowth disorders

PROS features generally include overgrowth of adipose, muscle, nerve, or skeletal tissue, vascular malformation, and skin lesions

The medical complications of PROS can compromise quality of life and social functioning in patients of all ages

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