Rare Endocrinology News
5 Facts you should know about
Dent disease
1
Dent disease is a rare X-linked recessive inherited condition that affects the proximal renal tubules of the kidney
2
While symptoms and severity vary, they usually begin in childhood and worsen over time
3
The most common feature of Dent disease is proteinuria
4
Other signs and symptoms include excess calcium in the urine, formation of calcium kidney stones, nephrocalcinosis, and chronic kidney failure
5
About 60% of patients have mutations in the CLCN5 gene (Dent 1), and 15% of patients have mutations in the OCRL1 gene (Dent 2)
Rare Endocrinology News
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