5 Facts you should know about

Bardet-Biedl Syndrome

Symptoms include retinal degeneration, obesity, reduced kidney function, and polydactyly

Patients with BBS can experience problems with obesity, specifically with fat deposition along the abdomen

BBS patients often experience hyperphagia - an abnormally strong, incessant sensation of hunger or desire to eat often leading to overeating

The melanocortin-4 receptor pathway (MC4R pathway) in the hypothalamus is responsible for regulating hunger, food intake, satiety, and energy expenditure

Impaired MC4R signaling can lead to early-onset, severe obesity and hyperphagia, irrespective of environmental and lifestyle factors

See our full disease profile

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