Rare Endocrinology News
5 Facts you should know about
Adrenoleukodystrophy
1
Long chain fatty acid buildup causes damage to the myelin sheath of the nerves of the brain, resulting in seizures and hyperactivity
2
The most severely affected tissues are the myelin in the central nervous system, the adrenal cortex, and the Leydig cells in the testes
3
Approximately two-thirds of ALD patients will present with the childhood cerebral form of the disease, which is the most severe form
4
Initial symptoms in boys affected with the childhood cerebral form of ALD include emotional instability, hyperactivity, and disruptive behavior at school
5
The severe form is characterized by normal development in early childhood, followed by rapid degeneration to a vegetative state
Rare Endocrinology News
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