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Disease Profile
Nontuberculous mycobacterial lung disease
Prevalence estimates on Rare Medical Network websites are calculated based on data available from numerous sources, including US and European government statistics, the NIH, Orphanet, and published epidemiologic studies. Rare disease population data is recognized to be highly variable, and based on a wide variety of source data and methodologies, so the prevalence data on this site should be assumed to be estimated and cannot be considered to be absolutely correct.
1-9 / 100 000
Age of onset
All ages
ICD-10
A31.0
Inheritance
Autosomal dominant A pathogenic variant in only one gene copy in each cell is sufficient to cause an autosomal dominant disease.
Autosomal recessive Pathogenic variants in both copies of each gene of the chromosome are needed to cause an autosomal recessive disease and observe the mutant phenotype.
X-linked
dominant X-linked dominant inheritance, sometimes referred to as X-linked dominance, is a mode of genetic inheritance by which a dominant gene is carried on the X chromosome.
dominant X-linked dominant inheritance, sometimes referred to as X-linked dominance, is a mode of genetic inheritance by which a dominant gene is carried on the X chromosome.
X-linked
recessive Pathogenic variants in both copies of a gene on the X chromosome cause an X-linked recessive disorder.
recessive Pathogenic variants in both copies of a gene on the X chromosome cause an X-linked recessive disorder.
Mitochondrial or multigenic Mitochondrial genetic disorders can be caused by changes (mutations) in either the mitochondrial DNA or nuclear DNA that lead to dysfunction of the mitochondria and inadequate production of energy.
Multigenic or multifactor Inheritance involving many factors, of which at least one is genetic but none is of overwhelming importance, as in the causation of a disease by multiple genetic and environmental factors.
Not applicable
Other names (AKA)
Non-tuberculous mycobacterial lung disease; Pulmonary non-tuberculous mycobacterial infection
Categories
Bacterial infections; Lung Diseases
Summary
Nontuberculous mycobacterial (NTM) lung disease is an infectious condition caused by certain types of mycobacteria. Some people with NTM lung disease have no signs or symptoms, while others experience a severe cough, hemoptysis (coughing up blood), shortness of breath, fatigue, fever, night sweats and/or weightloss. Mycobacteria are found naturally in soil and water. Most people who are exposed to these
Symptoms
This table lists symptoms that people with this disease may have. For most diseases, symptoms will vary from person to person. People with the same disease may not have all the symptoms listed. This information comes from a database called the Human Phenotype Ontology (HPO) . The HPO collects information on symptoms that have been described in medical resources. The HPO is updated regularly. Use the HPO ID to access more in-depth information about a symptom.
Medical Terms | Other Names |
Learn More:
HPO ID
|
---|---|---|
80%-99% of people have these symptoms | ||
Elevated |
High ESR
|
0003565 |
30%-79% of people have these symptoms | ||
Asthenia | 0025406 | |
Bronchiectasis |
Permanent enlargement of the airways of the lungs
|
0002110 |
Cough |
Coughing
|
0012735 |
Pulmonary opacity | 0031457 | |
5%-29% of people have these symptoms | ||
Chest pain | 0100749 | |
Chronic pulmonary obstruction | 0006510 | |
Crackles | 0030830 | |
Diarrhea |
Watery stool
|
0002014 |
Disseminated nontuberculous mycobacterial infection | 0032283 | |
Fever | 0001945 | |
Hemoptysis |
Coughing up blood
|
0002105 |
Lymphadenopathy |
Swollen lymph nodes
|
0002716 |
Mycobacterium abscessus abscessus infection | 0032130 | |
Pericardial effusion |
Fluid around heart
|
0001698 |
Pleural effusion |
Fluid around lungs
|
0002202 |
Respiratory distress |
Breathing difficulties
Difficulty breathing
[ more ] |
0002098 |
Weight loss | 0001824 | |
1%-4% of people have these symptoms | ||
Pneumothorax |
Collapsed lung
|
0002107 |
Organizations
Support and advocacy groups can help you connect with other patients and families, and they can provide valuable services. Many develop patient-centered information and are the driving force behind research for better treatments and possible cures. They can direct you to research, resources, and services. Many organizations also have experts who serve as medical advisors or provide lists of doctors/clinics. Visit the group’s website or contact them to learn about the services they offer. Inclusion on this list is not an endorsement by GARD.
Organizations Supporting this Disease
-
NTM Info & Research (supports pulmonary NTM infections)
550 Madruga Avenue, Suite 230
Coral Gables, FL 33146
Telephone: 305-667-6461, ext 26 and 32
E-mail: [email protected]
Website: https://www.ntminfo.org/
Organizations Providing General Support
-
American Lung Association
55 W. Wacker Drive, Suite 1150
Chicago, IL 60601
Toll-free: 1-800-548-8252 (1-800-LUNGUSA)
E-mail: [email protected]
Website: https://www.lung.org/
Learn more
These resources provide more information about this condition or associated symptoms. The in-depth resources contain medical and scientific language that may be hard to understand. You may want to review these resources with a medical professional.
In-Depth Information
- Orphanet is a European reference portal for information on rare diseases and orphan drugs. Access to this database is free of charge.
- PubMed is a searchable database of medical literature and lists journal articles that discuss Nontuberculous mycobacterial lung disease. Click on the link to view a sample search on this topic.
References
- Learn about Nontuberculous Mycobacteria (NTM). American Lung Association. https://www.lung.org/lung-health-and-diseases/lung-disease-lookup/nontuberculosis-mycobacteria/learn-about-ntm.html. Accessed 11/2/2015.
- Johnson MM & Odell JA. Nontuberculous mycobacterial pulmonary infections. J Thorac Dis. March, 2014; 6(3):210–220. https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3949190/. Accessed 11/2/2015.
- Griffith DE. Diagnosis of nontuberculous mycobacterial infections of the lungs in HIV-negative patients. UpToDate. August 20, 2015; https://www.uptodate.com/contents/diagnosis-of-nontuberculous-mycobacterial-infections-of-the-lungs-in-hiv-negative-patients. Accessed 11/2/2015.